MOSCOW, December 14The technology for a full cycle of serial production of microchips for the synthesis of complex organic compounds, including those for specific tasks, was localized by scientists from the Southern Federal University as part of an international scientific team. According to the authors of the development, the microchip can be used in medicine, cosmetology, food and chemical industries. The results are presented in the New Journal of Chemistry.
According to scientists from the Southern Federal University (SFU), small-scale production of organic compounds is a complex technological process that requires precise compliance with the conditions for chemical reactions. Accuracy is especially important in the synthesis of biologically active substances used in medicine, cosmetology and the food industry, as well as for the production of catalysts.
Nowadays, “stationary” methods for the synthesis of organic compounds are used; a mixture of reagents is supplied at a set temperature and pressure into a container, where it is kept for a strictly defined time, SFU specialists explained. At the same time, monitoring the parameters inside the container is difficult, since the reagents are often aggressive towards the sensor materials.
SFU researchers, together with Russian and Bulgarian colleagues, proposed synthesizing biologically active molecules using microfluidics methods (the science of matter that studies small volumes of liquids and gases and the possibility of controlling processes in microchip channels having a micron size).
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“During the study, we identified a significant advantage in the yield of reaction products and mass productivity (kilograms per hour) of microfluidic methods in comparison with “classical” ones. It was also possible to synthesize promising organic molecules with multidirectional activity,” said one of the authors of the publication, an engineer at the research laboratory “Microfluidic Technologies for Accelerated Synthesis of Materials.” SFU Alexander Zagrebaev.
According to Zagrebaev, a comparison of microfluidic methods with classical ones shows an increase in the yield of target compounds by 30%.
“We were able to synthesize promising organic molecules with multidirectional activities. Although the work describes in detail the antioxidant activity, it is worth noting that this activity does not exhaust the full range of biological properties of these substances. Further study of various aspects of their biological activity is planned,” noted Zagrebaev.
The study, in which scientists from SFU, the North Caucasus Federal University (NCFU), the Federal Research Center for Problems of Chemical Physics and Medical Chemistry of the Russian Academy of Sciences and the Institute of General and Inorganic Chemistry of the Bulgarian Academy of Sciences took part, was carried out within the framework of the SFU strategic project “Full-cycle technologies for express development of functional materials for a low-carbon economy under the control of artificial intelligence” of the federal program “Priority 2030” of the national project “Science and Universities”.
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