Russia has created a new complex to combat osteoporosis

MOSCOW, July 30 BelSU scientists have developed the basis of a new pharmacological compound for restoring bone tissue and strengthening it. According to them, the basic component of the drug has higher bioavailability compared to existing analogues, which will increase the effectiveness of osteoporosis treatment and reduce the number of side effects. The results have been patented and presented in a number of scientific publications.
Osteoporosis is a metabolic disease that leads to a decrease in bone mass, causing the skeleton to become more fragile. Various factors can lead to osteoporosis: from calcium deficiency to long-term use of hormonal drugs. However, according to statistics, older people are most susceptible to osteoporosis, said specialists from Belgorod State University (BelSU).

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"With the aging population growing, osteoporosis is becoming a global problem. According to various estimates, by 2050, half of fractures will occur due to this disease,” emphasized one of the authors of the study, Associate Professor of the Department of Pharmacology and Clinical Pharmacology of the Medical Institute, Head of the Laboratory of Preclinical Research of the Research Institute of Pharmacology of Living Systems of Belgorod State University Oleg Gudyrev.

Currently, there are a large number of classes of drugs for osteoporosis, the vast majority of which do not show sufficient effectiveness, but give many side effects, the specialist emphasized. Therefore, there is a need to create new drugs to strengthen the body's bone tissue.

A team of Belgorod State University scientists has studied a new supramolecular complex for strengthening and mineralizing bone tissue, developed under the supervision of Professor Sofia Skachilova, based on acexamic acid, which is used for wound healing. However, in its «pure» form, it is poorly absorbed by the body, so salts and complexes based on it are used as medicines.

«We have studied a new acexamic acid complex synthesized by our colleagues, which is absorbed by bone tissue at least 7 times more effectively than compounds with a similar structure. It also accumulates better: the maximum concentration in bones is 40 times higher,» Gudyrev explained.
He added that after conducting additional experiments, the researchers plan to begin developing an oral drug for osteoporosis.

The Press Service of the National Research University «BelSU», which is implementing the «Scientific Belgorod» project with the support of a grant from the Ministry of Education and Science of the Russian Federation of the federal project «Popularization of Science and Technology», noted that after conducting additional experiments, the researchers plan to begin developing an oral drug for osteoporosis.