MOSCOW, December 2. Scientists at NCFU have developed a method for creating nano-sized biometal silicates stabilized by the essential amino acid L-lysine. These particles can be used in implantology and other areas of medicine, as well as in industry, experts explained. The research results are presented in Micromachines.
Nanosized biometal silicates are salts of silicic acids of mono- and divalent metals (calcium, zinc, magnesium, cobalt, iron, manganese and others), which have high biological activity. They can serve as a source of essential microelements in dietary supplements and strengthen the body's muscle and bone tissue. They can be used in implantology, light industry and construction, as well as in the creation of phosphors and conductors.
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Such a wide range of applications requires methods that would ensure the production of raw materials of a given quality on an industrial scale. Today, silicates of mono- and divalent metals are produced by chemical and physical methods in the presence of catalysts. However, the physical method requires significant energy consumption with a low yield of the finished product.
In turn, many chemical methods are not flexible in obtaining silicates of divalent metals, in particular cobalt and zinc, and the purity of the finished product also suffers.
Employees of the Department of Physics and Technology of Nanostructures and Materials of the Faculty of Physics and Technology of the North Caucasus Federal University (NCFU) have developed an accessible method for producing nano-sized biometal silicates stabilized by the essential amino acid L-lysine. According to the authors, the amino acid prevents particles of the substance from sticking together, so the raw materials obtained by the new method can be stored for a long time.
July 1, 08:00
To obtain stabilized nanosized biometal silicates, a solution of biometal acetate, sodium silicate and the amino acid L-lysine is prepared in a glass reactor. The resulting mixture is stirred and then exposed to ultrasound. The treated gel is washed three times with distilled water in a centrifuge. The washed gel is dried at a temperature of 80°C for 12 hours. The invention makes it possible to obtain a dry powder of a homogeneous structure without odor or foreign inclusions.
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“The developed biometal silicates in a nanosized state have unique medical properties, their biological, antibacterial, osteogenic and anionogenic activities increase, which has a positive effect on the process of healing and restoration of bone tissue,” said Associate Professor of the Department of Physics and Technology of Nanostructures and Materials of the Faculty of Physics and Technology NCFU Anastasia Blinova.
She noted that in implantology, to create a reliable biocompatible implant coating, it is important to use nano-sized structures that are part of human bones. One of these components is the amino acid L-lysine. It is involved in strengthening bones and is responsible for the adsorption of calcium and other biometals, thereby affecting the strength of tissues and helping the implant to take root better in the body. That is why scientists chose this substance.
“The cost of development is much lower than analogues due to its nanosize, the working concentrations of the components used are much lower than usual with the same efficiency. Dental clinics that specialize in dental implantation have already become interested in the development “, noted Blinova.
Researchers have patented a new technology and are now studying the toxicological characteristics of nano-sized biometal silicates and their biocompatibility with the body.
The research was carried out with the financial support of the Grant Council of the President of the Russian Federation (project SP-476.2022.4).
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