MOSCOW, July 3New compounds to suppress the growth of cancer tumors were synthesized by SPbPU scientists as part of a scientific team. According to the authors, the resulting substances are several times more effective than traditional ones in reducing the volume of tumors in melanoma – skin cancer. The results are presented in the journal Bioorganic Chemistry.
According to WHO, malignant tumors are one of the leading causes of death in the world, but many types are curable with timely diagnosis and proper therapy.
One of the most effective cancer treatments today is chemotherapy, which allows aggressive chemicals to destroy tumors regardless of their location in the body, according to Peter the Great St. Petersburg Polytechnic University (SPbPU).
According to experts, traditional chemotherapy drugs have a pronounced toxic effect on healthy tissues of the body, so today scientists are faced with the task of developing safer drugs.
SPbPU researchers together with colleagues from other domestic universities have synthesized new pyrrolothienopyrimidine derivatives are compounds that potentially have high biological activity.
Experts assessed the effectiveness of the resulting substances against cancer tumors both using melanoma cell cultures in vitro and during experiments on laboratory animals. According to the researchers, six compounds demonstrated significant antitumor effects against melanoma, breast and colorectal cancer cells.
Experts have found that the most effective compound is four times more active than traditional substances in reducing the volume of tumors that arose in a mouse model of melanoma.
The university noted that during experiments on laboratory animals, no pathological changes were found in the main organs (heart, lungs, liver, spleen and kidneys), suggesting the absence of general toxicity of the material.
““Synthesized compounds will improve the effectiveness of cancer therapy and improve the quality of life of patients with cancer. Their use will also create the prerequisites for the formation and scaling of technologies for the production of domestic pharmaceuticals, and implement import substitution in the pharmaceutical industry,” said one of the authors of the development, a research assistant. Laboratory of Nano- and Microencapsulation of Biologically Active Substances of St. Petersburg Polytechnic University Anna Rogova.
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Now the team of scientists is faced with the task of studying the safety of the resulting compounds in more detail; for this, experts are planning to conduct preclinical and clinical studies.
Specialists from Peter the Great St. Petersburg Polytechnic University, ITMO University, and the Institute of Ecology and Genetics took part in the study microorganisms of the Ural Branch of the Russian Academy of Sciences, Perm State National Research University, Academic University named after. Zh.I. Alferov, PNIPU and the Institute of Pediatric Oncology, Hematology and Transplantology named after R.M. Gorbachev.
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