TOKYO, February 13 For the first time, Japanese scientists have succeeded in cloning a pig bred in the USA, suitable for cross-species organ transplantation, including to humans, according to a press release from PorMedTec. , engaged in similar developments under the auspices of Meiji University.
«Meiji University-based venture capital firm PorMedTec and US biotechnology company eGenesis, which develops organs and cells suitable for human transplantation, have successfully produced genetically modified cloned pigs for xenotransplantation for the first time in Japan. Three pigs were born on February 11 and will be provided in the future medical institutions in Japan for preclinical studies,» the document says.
Founded in 2015, the American company eGenesis last fall presented the results of research in which they transplanted the kidneys of dwarf domestic pigs, the genome of which was modified to make tissues compatible with organisms of other species, in this case primates.
The maximum life expectancy of macaques with kidneys transplanted from such animals was 758 days.
«The shortage of organ donors in transplant medicine is a pressing global problem. In recent years, in Japan, only about 3% of applicants can actually receive organ transplantation. One of the reasons for this is the extreme shortage of organ donors,» the press release notes. .
To help solve this problem, in September 2023, PolMedTech imported genetically modified pig cells from eGenesis and used somatic nuclear cloning technology developed by the International Institute of Bioresources at Meiji University to create cloned piglets. The piglets are expected to be transferred to research institutes in Japan to begin research on organ transplantation in primates before the end of this year.
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